コリンモノオキシゲナーゼ
コリンモノオキシゲナーゼ（choline monooxygenase）は、グリシン、セリン、トレオニン代謝酵素の一つで、次の化学反応を触媒する酸化還元酵素である。
- コリン + O2 + 2 還元型フェレドキシン + 2 H+ ベタインアルデヒド水和物 + H2O + 2 酸化型フェレドキシン
この酵素の基質はコリン、O2、還元型フェレドキシンとH+で、生成物はベタインアルデヒド水和物、酸化型フェレドキシンとH2Oである。
組織名はcholine,reduced-ferredoxin:oxygen oxidoreductaseである。
参考文献
- Brouquisse R, Weigel P, Rhodes D, Yocum CF and Hanson AD (1989). “Evidence for a ferredoxin-dependent choline monooxygenase from spinach chloroplast stroma”. Plant Physiol. 90: 322–329. doi:10.1104/pp.90.1.322.
- Burnet M, Lafontaine PJ, Hanson AD (1995). “Assay, Purification, and Partial Characterization of Choline Monooxygenase from Spinach”. Plant. Physiol. 108 (2): 581–588. PMC 157377. PMID 12228495.
- Scott P, Golbeck JH, Hanson AD (1997). “Choline monooxygenase, an unusual iron-sulfur enzyme catalyzing the first step of glycine betaine synthesis in plants: prosthetic group characterization and cDNA cloning”. Proc. Natl. Acad. Sci. U. S. A. 94 (7): 3454–8. doi:10.1073/pnas.94.7.3454. PMC 20391. PMID 9096415.
- Russell BL, Rathinasabapathi B, Hanson AD (1998). “Osmotic stress induces expression of choline monooxygenase in sugar beet and amaranth”. Plant. Physiol. 116 (2): 859–65. doi:10.1104/pp.116.2.859. PMC 35146. PMID 9489025.
- Gage DA and Hanson AD (1998). “Glycine betaine synthesis in transgenic tobacco expressing choline monooxygenase is limited by the endogenous choline supply”. Plant J. 16: 101–110. doi:10.1046/j.1365-313x.1998.00274.x.
- AD; Russell, BL; Nolte, KD; Rathinasabapathi, B; Gage, DA; Hanson, AD (1998). “The endogenous choline supply limits glycine betaine synthesis in transgenic tobacco expressing choline monooxygenase”. Plant. J. 16 (4): 487–96. doi:10.1046/j.1365-313x.1998.00316.x. PMID 9881168.
- Takabe T; Tanaka, Y; Aoki, K; Hibino, T; Jikuya, H; Takano, J; Takabe, T; Takabe, T (2003). “Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica”. J. Biol. Chem. 278 (7): 4932–42. doi:10.1074/jbc.M210970200. PMID 12466265.
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