プロガストリシン
機能
プロガストリシンは、ペプチダーゼファミリーA1のアスパラギン酸プロテアーゼである。コードされたタンパク質は胃で産生される消化酵素で、胃粘膜の主要な構成成分である。また、血清中にも分泌される。強塩基性のプロセグメントを含む不活性酵素前駆体として合成される。低pHで酵素自体によって行われるプロセグメントの一連の切断により、活性を持つ成熟型に変換される[4]。
出典
- “Primary structure of human pepsinogen C gene”. J. Biol. Chem. 263 (3): 1382–5. (January 1988). doi:10.1016/S0021-9258(19)57314-8. PMID 3335549.
- “Human pepsinogen C (progastricsin) polymorphism: evidence for a single locus located at 6p21.1-pter”. Genomics 4 (2): 137–48. (February 1989). doi:10.1016/0888-7543(89)90292-9. PMID 2567697.
- “Human pepsinogen C (progastricsin). Isolation of cDNA clones, localization to chromosome 6, and sequence homology with pepsinogen A”. J. Biol. Chem. 264 (1): 375–9. (January 1989). doi:10.1016/S0021-9258(17)31268-1. PMID 2909526.
- “Entrez Gene: PGC progastricsin (pepsinogen C)”. 2022年9月11日閲覧。
関連文献
- “Mechanism of activation of the gastric aspartic proteinases: pepsinogen, progastricsin and prochymosin.”. Biochem. J. 335 (3): 481–90. (1998). doi:10.1042/bj3350481. PMC 1219805. PMID 9794784.
- “Isolation and characterization of a pepsin C zymogen produced by human breast tissues.”. J. Biol. Chem. 267 (34): 24725–31. (1992). doi:10.1016/S0021-9258(18)35824-1. PMID 1280267.
- “Methylation and expression of human pepsinogen genes in normal tissues and their alteration in stomach cancer.”. Jpn. J. Cancer Res. 82 (6): 686–92. (1991). doi:10.1111/j.1349-7006.1991.tb01904.x. PMC 5918501. PMID 1906854.
- “A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins.”. J. Biochem. 106 (5): 920–7. (1990). doi:10.1093/oxfordjournals.jbchem.a122952. PMID 2515193.
- “Gastric proteases in Barrett's esophagus.”. Gastroenterology 93 (4): 774–8. (1987). doi:10.1016/0016-5085(87)90439-2. PMID 3305135.
- “Human progastricsin. Analysis of intermediates during activation into gastricsin and determination of the amino acid sequence of the propart.”. Eur. J. Biochem. 128 (1): 63–70. (1983). doi:10.1111/j.1432-1033.1982.tb06931.x. PMID 6816595.
- “Crystal and molecular structures of human progastricsin at 1.62 A resolution.”. J. Mol. Biol. 247 (3): 466–85. (1995). doi:10.1006/jmbi.1994.0154. PMID 7714902.
- “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.”. Gene 138 (1–2): 171–4. (1994). doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- “Pepsinogen A and C serum levels in relation to acute NSAID-associated mucosal lesions in healthy volunteers.”. Scand. J. Gastroenterol. 28 (6): 557–60. (1993). doi:10.3109/00365529309098266. PMID 8322031.
- “Purification of pepsinogens from human urine and electrophoretic analysis by caseogram print.”. Biochem. Mol. Biol. Int. 39 (6): 1147–56. (1997). doi:10.1080/15216549600201332. PMID 8876968.
- “Immunofluorometric assay of pepsinogen C and preliminary clinical applications.”. Clin. Chem. 43 (8 Pt 1): 1365–71. (1997). doi:10.1093/clinchem/43.8.1365. PMID 9267315.
- “Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.”. Gene 200 (1–2): 149–56. (1997). doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- “Structural characterization of activation 'intermediate 2' on the pathway to human gastricsin.”. Nat. Struct. Biol. 4 (12): 1010–5. (1998). doi:10.1038/nsb1297-1010. PMID 9406551.
- “Helicobacter pylori genotypes influence serum pepsinogen C levels.”. Helicobacter 2 (4): 172–5. (1998). doi:10.1111/j.1523-5378.1997.tb00082.x. PMID 9421118.
- “Expression and clinical significance of pepsinogen C in epithelial ovarian carcinomas.”. Eur. J. Obstet. Gynecol. Reprod. Biol. 104 (1): 58–63. (2003). doi:10.1016/S0301-2115(01)00610-8. PMID 12128264.
- “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. (2003). doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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