5β-コレスタン-3α,7α-ジオール-12α-ヒドロキシラーゼ
5β-コレスタン-3α,7α-ジオール-12α-ヒドロキシラーゼ（5β-cholestane-3α,7α-diol 12α-hydroxylase）は、次の化学反応を触媒する酸化還元酵素である。
- 5β-コレスタン-3α,7α-ジオール + NADPH + H+ + O2 5β-コレスタン-3α,7α,12α-トリオール + NADP+ + H2O
| 5β-コレスタン-3α,7α-ジオール-12α-ヒドロキシラーゼ | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 識別子 | |||||||||
| EC番号 | 1.14.13.96 | ||||||||
| データベース | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB構造 | RCSB PDB PDBj PDBe PDBsum | ||||||||
| |||||||||
この酵素の基質は5β-コレスタン-3α,7α-ジオール、NADPH、H+とO2で、生成物は5β-コレスタン-3α,7α,12α-トリオール、NADP+とH2Oである。
組織名は5β-cholestane-3α,7α-diol,NADPH:oxygen oxidoreductase (12α-hydroxylating)で、別名に5β-cholestane-3α,7α-diol 12α-monooxygenase、sterol 12α-hydroxylase (ambiguous)、CYP8B1、cytochrome P450 8B1がある。
参考文献
- Hansson R, Wikvall K (1982). “Hydroxylations in biosynthesis of bile acids. Cytochrome P-450 LM4 and 12α-hydroxylation of 5beta-cholestane-3α, 7α-diol”. Eur. J. Biochem. 125 (2): 423–9. doi:10.1111/j.1432-1033.1982.tb06700.x. PMID 6811268.
- Hansson R, Wikvall K (1980). “Hydroxylations in biosynthesis and metabolism of bile acids Catalytic properties of different forms of cytochrome P-450”. J. Biol. Chem. 255 (4): 1643–9. PMID 6766451.
- Lundell K, Wikvall K (2003). “Gene structure of pig sterol 12α-hydroxylase (CYP8B1) and expression in fetal liver: comparison with expression of taurochenodeoxycholic acid 6α-hydroxylase (CYP4A21)”. Biochim. Biophys. Acta. 1634 (3): 86–96. PMID 14643796.
- G, Martens S; Matern, U; Junghanns, KT; Heskamp, ML; Britsch, L; Forkmann, G; Martens, S (2001). “Purification and antigenicity of flavone synthase I from irradiated parsley cells”. Arch. Biochem. Biophys. 393 (1): 177–83. doi:10.1006/abbi.2001.2491. PMID 11516175.
- Yang Y, Zhang M, Eggertsen G, Chiang JY (2002). “On the mechanism of bile acid inhibition of rat sterol 12α-hydroxylase gene (CYP8B1) transcription: roles of α-fetoprotein transcription factor and hepatocyte nuclear factor 4α”. Biochim. Biophys. Acta. 1583 (1): 63–73. PMID 12069850.
- Russell DW (2003). “The enzymes, regulation, and genetics of bile acid synthesis”. Annu. Rev. Biochem. 72: 137–74. doi:10.1146/annurev.biochem.72.121801.161712. PMID 12543708.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.