all-trans-ノナプレニル二リン酸シンターゼ (ゲラニル二リン酸特異的)

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all-trans-ノナプレニル二リン酸シンターゼ (ゲラニル二リン酸特異的)
識別子
EC番号	2.5.1.84
データベース
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB構造	RCSB PDB PDBj PDBe PDBsum
検索
PMC	articles
PubMed	articles
NCBI	proteins

all-trans-ノナプレニル二リン酸シンターゼ (ゲラニル二リン酸特異的)(all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific))はユビキノンの合成に関わるプレニル基転移酵素の1つで、次の化学反応を触媒する酵素である。

ゲラニル二リン酸 + 7 イソペンテニル二リン酸

\rightleftharpoons

7 二リン酸 + all-trans-ノナプレニル二リン酸

組織名はgeranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 7 isopentenyl units)である。

分布

Micrococcus luteus（放線菌門）[1][2][3][4]、イネ[5]、ラット[6]などに存在している。

参考文献

Sagami, H.; Ogura, K.; Seto, S. (1977). “Solanesyl pyrophosphate synthetase from Micrococcus lysodeikticus”. Biochemistry 16: 4616–4622. doi:10.1021/bi00640a014. PMID 911777.
Fujii, H.; Sagami, H.; Koyama, T.; Ogura, K.; Seto, S.; Baba, T.; Allen, C.M. (1980). “Variable product specificity of solanesyl pyrophosphate synthetase”. Biochem. Biophys. Res. Commun. 96: 1648–1653. doi:10.1016/0006-291X(80)91363-7. PMID 7447947.
Ohnuma, S.; Koyama, T.; Ogura, K. (1991). “Purification of solanesyl-diphosphate synthase from Micrococcus luteus. A new class of prenyltransferase”. J. Biol. Chem. 266 (35): 23706–23713. PMID 1748647.
Gotoh, T.; Koyama, T.; Ogura, K. (1992). “Farnesyl diphosphate synthase and solanesyl diphosphate synthase reactions of diphosphate-modified allylic analogs: the significance of the diphosphate linkage involved in the allylic substrates for prenyltransferase”. J. Biochem. 112 (1): 20–27. PMID 1429508.
Ohara, K.; Sasaki, K.; Yazaki, K. (2010). “Two solanesyl diphosphate synthases with different subcellular localizations and their respective physiological roles in Oryza sativa”. J. Exp. Bot. 61 (10): 2683–92. doi:10.1093/jxb/erq103. PMC 2882263. PMID 20421194.
Teclebrhan, H.; Olsson, J.; Swiezewska, E.; Dallner, G. (1993). “Biosynthesis of the side chain of ubiquinone:trans-prenyltransferase in rat liver microsomes”. J. Biol. Chem. 268 (31): 23081–23086. PMID 8226825.

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[1] Sagami, H.; Ogura, K.; Seto, S. (1977). “Solanesyl pyrophosphate synthetase from Micrococcus lysodeikticus”. Biochemistry 16: 4616–4622. doi:10.1021/bi00640a014. PMID 911777.

[2] Fujii, H.; Sagami, H.; Koyama, T.; Ogura, K.; Seto, S.; Baba, T.; Allen, C.M. (1980). “Variable product specificity of solanesyl pyrophosphate synthetase”. Biochem. Biophys. Res. Commun. 96: 1648–1653. doi:10.1016/0006-291X(80)91363-7. PMID 7447947.

[3] Ohnuma, S.; Koyama, T.; Ogura, K. (1991). “Purification of solanesyl-diphosphate synthase from Micrococcus luteus. A new class of prenyltransferase”. J. Biol. Chem. 266 (35): 23706–23713. PMID 1748647.

[4] Gotoh, T.; Koyama, T.; Ogura, K. (1992). “Farnesyl diphosphate synthase and solanesyl diphosphate synthase reactions of diphosphate-modified allylic analogs: the significance of the diphosphate linkage involved in the allylic substrates for prenyltransferase”. J. Biochem. 112 (1): 20–27. PMID 1429508.

[5] Ohara, K.; Sasaki, K.; Yazaki, K. (2010). “Two solanesyl diphosphate synthases with different subcellular localizations and their respective physiological roles in Oryza sativa”. J. Exp. Bot. 61 (10): 2683–92. doi:10.1093/jxb/erq103. PMC 2882263. PMID 20421194.

[6] Teclebrhan, H.; Olsson, J.; Swiezewska, E.; Dallner, G. (1993). “Biosynthesis of the side chain of ubiquinone:trans-prenyltransferase in rat liver microsomes”. J. Biol. Chem. 268 (31): 23081–23086. PMID 8226825.